| 1 | Christian McCaffrey CAR - at IND | Christian McCaffrey CAR - at IND |
| 2 | Chris Carson SEA - vs. ARI | Chris Carson SEA - vs. ARI |
| 3 | Saquon Barkley NYG - at WAS | Saquon Barkley NYG - at WAS |
| 4 | Ezekiel Elliott DAL - at PHI | Ezekiel Elliott DAL - at PHI |
| 5 | Joe Mixon CIN - at MIA | Derrick Henry TEN - vs. NO |
| 6 | Leonard Fournette JAC - at ATL | Leonard Fournette JAC - at ATL |
| 7 | Derrick Henry TEN - vs. NO | Nick Chubb CLE - vs. BAL |
| 8 | Mark Ingram BAL - at CLE | Joe Mixon CIN - at MIA |
| 9 | Nick Chubb CLE - vs. BAL | Mark Ingram BAL - at CLE |
| 10 | Melvin Gordon LAC - vs. OAK | Alvin Kamara NO - at TEN |
| 11 | Alvin Kamara NO - at TEN | Miles Sanders PHI - vs. DAL |
| 12 | Austin Ekeler LAC - vs. OAK | Austin Ekeler LAC - vs. OAK |
| 13 | Marlon Mack IND - vs. CAR | Todd Gurley LAR - at SF |
| 14 | Josh Jacobs OAK - at LAC | Phillip Lindsay DEN - vs. DET |
| 15 | Aaron Jones GB - at MIN | Aaron Jones GB - at MIN |
| 16 | Todd Gurley LAR - at SF | Raheem Mostert SF - vs. LAR |
| 17 | Miles Sanders PHI - vs. DAL | Devonta Freeman ATL - vs. JAC |
| 18 | Devonta Freeman ATL - vs. JAC | Melvin Gordon LAC - vs. OAK |
| 19 | Phillip Lindsay DEN - vs. DET | Kenyan Drake ARI - at SEA |
| 20 | Kenyan Drake ARI - at SEA | Marlon Mack IND - vs. CAR |
| 21 | James Conner PIT - at NYJ | Mike Boone MIN - vs. GB |
| 22 | Raheem Mostert SF - vs. LAR | Le'Veon Bell NYJ - vs. PIT |
| 23 | David Montgomery CHI - vs. KC | Adrian Peterson WAS - vs. NYG |
| 24 | Adrian Peterson WAS - vs. NYG | Devin Singletary BUF - at NE |
| 25 | Le'Veon Bell NYJ - vs. PIT | James Conner PIT - at NYJ |
| 26 | Mike Boone MIN - vs. GB | David Montgomery CHI - vs. KC |
| 27 | James White NE - vs. BUF | James White NE - vs. BUF |
| 28 | Devin Singletary BUF - at NE | Ronald Jones II TB - vs. HOU |
| 29 | Patrick Laird MIA - vs. CIN | Sony Michel NE - vs. BUF |
| 30 | Kareem Hunt CLE - vs. BAL | Patrick Laird MIA - vs. CIN |
| 31 | Royce Freeman DEN - vs. DET | Kareem Hunt CLE - vs. BAL |
| 32 | Ronald Jones II TB - vs. HOU | DeAndre Washington OAK - at LAC |
| 33 | Carlos Hyde HOU - at TB | Carlos Hyde HOU - at TB |
| 34 | Sony Michel NE - vs. BUF | Jamaal Williams GB - at MIN |
| 35 | Tarik Cohen CHI - vs. KC | Tarik Cohen CHI - vs. KC |
| 36 | Jamaal Williams GB - at MIN | Damian Williams KC - at CHI |
| 37 | David Johnson ARI - at SEA | Latavius Murray NO - at TEN |
| 38 | Boston Scott PHI - vs. DAL | Boston Scott PHI - vs. DAL |
| 39 | Latavius Murray NO - at TEN | Kerryon Johnson DET - at DEN |
| 40 | LeSean McCoy KC - at CHI | Miles Gaskin MIA - vs. CIN |
| 41 | Peyton Barber TB - vs. HOU | Royce Freeman DEN - vs. DET |
| 42 | Matt Breida SF - vs. LAR | Duke Johnson HOU - at TB |
| 43 | Chris Thompson WAS - vs. NYG | Peyton Barber TB - vs. HOU |
| 44 | Duke Johnson HOU - at TB | Nyheim Hines IND - vs. CAR |
| 45 | Nyheim Hines IND - vs. CAR | Gus Edwards BAL - at CLE |
| 46 | Gus Edwards BAL - at CLE | Chris Thompson WAS - vs. NYG |
| 47 | Dalvin Cook MIN - vs. GB | Matt Breida SF - vs. LAR |
| 48 | DeAndre Washington OAK - at LAC | Jalen Richard OAK - at LAC |
| 49 | Jalen Richard OAK - at LAC | David Johnson ARI - at SEA |
| 50 | Kerryon Johnson DET - at DEN | Jaylen Samuels PIT - at NYJ |
