| 1 | Christian McCaffrey CAR - vs. ATL | Christian McCaffrey CAR - vs. ATL |
| 2 | Dalvin Cook MIN - vs. DEN | Dalvin Cook MIN - vs. DEN |
| 3 | Ezekiel Elliott DAL - at DET | Ezekiel Elliott DAL - at DET |
| 4 | Josh Jacobs OAK - vs. CIN | Leonard Fournette JAC - at IND |
| 5 | Leonard Fournette JAC - at IND | Josh Jacobs OAK - vs. CIN |
| 6 | Melvin Gordon LAC - vs. KC | Nick Chubb CLE - vs. PIT |
| 7 | Le'Veon Bell NYJ - at WAS | James Conner PIT - at CLE |
| 8 | Nick Chubb CLE - vs. PIT | Marlon Mack IND - vs. JAC |
| 9 | Marlon Mack IND - vs. JAC | Melvin Gordon LAC - vs. KC |
| 10 | Damien Williams KC - at LAC | Tevin Coleman SF - vs. ARI |
| 11 | Mark Ingram BAL - vs. HOU | Mark Ingram BAL - vs. HOU |
| 12 | Devin Singletary BUF - at MIA | Le'Veon Bell NYJ - at WAS |
| 13 | Tevin Coleman SF - vs. ARI | Alvin Kamara NO - at TB |
| 14 | Alvin Kamara NO - at TB | Damien Williams KC - at LAC |
| 15 | Brian Hill ATL - at CAR | Todd Gurley LAR - vs. CHI |
| 16 | Austin Ekeler LAC - vs. KC | Devin Singletary BUF - at MIA |
| 17 | Joe Mixon CIN - at OAK | Brian Hill ATL - at CAR |
| 18 | Ronald Jones II TB - vs. NO | David Montgomery CHI - at LAR |
| 19 | Todd Gurley LAR - vs. CHI | Joe Mixon CIN - at OAK |
| 20 | James Conner PIT - at CLE | Phillip Lindsay DEN - at MIN |
| 21 | David Montgomery CHI - at LAR | Sony Michel NE - at PHI |
| 22 | James White NE - at PHI | Carlos Hyde HOU - at BAL |
| 23 | Phillip Lindsay DEN - at MIN | Ronald Jones II TB - vs. NO |
| 24 | Jordan Howard PHI - vs. NE | Austin Ekeler LAC - vs. KC |
| 25 | Sony Michel NE - at PHI | Adrian Peterson WAS - vs. NYJ |
| 26 | Kenyan Drake ARI - at SF | Jordan Howard PHI - vs. NE |
| 27 | Derrius Guice WAS - vs. NYJ | Royce Freeman DEN - at MIN |
| 28 | Carlos Hyde HOU - at BAL | James White NE - at PHI |
| 29 | Adrian Peterson WAS - vs. NYJ | Kalen Ballage MIA - vs. BUF |
| 30 | Jaylen Samuels PIT - at CLE | J.D. McKissic DET - vs. DAL |
| 31 | Kareem Hunt CLE - vs. PIT | Miles Sanders PHI - vs. NE |
| 32 | Royce Freeman DEN - at MIN | Kenyan Drake ARI - at SF |
| 33 | J.D. McKissic DET - vs. DAL | Frank Gore BUF - at MIA |
| 34 | Frank Gore BUF - at MIA | Kareem Hunt CLE - vs. PIT |
| 35 | Tarik Cohen CHI - at LAR | Duke Johnson HOU - at BAL |
| 36 | Miles Sanders PHI - vs. NE | Raheem Mostert SF - vs. ARI |
| 37 | Kalen Ballage MIA - vs. BUF | Jeff Wilson SF - vs. ARI |
| 38 | Alexander Mattison MIN - vs. DEN | Latavius Murray NO - at TB |
| 39 | Latavius Murray NO - at TB | LeSean McCoy KC - at LAC |
| 40 | Ty Johnson DET - vs. DAL | Tarik Cohen CHI - at LAR |
| 41 | Duke Johnson HOU - at BAL | Derrius Guice WAS - vs. NYJ |
| 42 | Peyton Barber TB - vs. NO | David Johnson ARI - at SF |
| 43 | David Johnson ARI - at SF | Alexander Mattison MIN - vs. DEN |
| 44 | Nyheim Hines IND - vs. JAC | Gus Edwards BAL - vs. HOU |
| 45 | Gus Edwards BAL - vs. HOU | Jaylen Samuels PIT - at CLE |
| 46 | Darrell Henderson LAR - vs. CHI | Ty Johnson DET - vs. DAL |
| 47 | Rex Burkhead NE - at PHI | Peyton Barber TB - vs. NO |
| 48 | Darrel Williams KC - at LAC | Rex Burkhead NE - at PHI |
| 49 | LeSean McCoy KC - at LAC | Paul Perkins DET - vs. DAL |
| 53 | Tony Pollard DAL - at DET | Darrel Williams KC - at LAC |
