| 1 | Christian McCaffrey CAR - vs. SEA | Christian McCaffrey CAR - vs. SEA |
| 2 | Dalvin Cook MIN - at LAC | Dalvin Cook MIN - at LAC |
| 3 | Derrick Henry TEN - vs. HOU | Derrick Henry TEN - vs. HOU |
| 4 | Ezekiel Elliott DAL - vs. LAR | Chris Carson SEA - at CAR |
| 5 | Chris Carson SEA - at CAR | Ezekiel Elliott DAL - vs. LAR |
| 6 | Leonard Fournette JAC - at OAK | Nick Chubb CLE - at ARI |
| 7 | Saquon Barkley NYG - vs. MIA | Leonard Fournette JAC - at OAK |
| 8 | Nick Chubb CLE - at ARI | Aaron Jones GB - vs. CHI |
| 9 | Mark Ingram BAL - vs. NYJ | Alvin Kamara NO - vs. IND |
| 10 | Alvin Kamara NO - vs. IND | Mark Ingram BAL - vs. NYJ |
| 11 | Todd Gurley LAR - at DAL | Saquon Barkley NYG - vs. MIA |
| 12 | Melvin Gordon LAC - vs. MIN | Melvin Gordon LAC - vs. MIN |
| 13 | Phillip Lindsay DEN - at KC | Todd Gurley LAR - at DAL |
| 14 | Aaron Jones GB - vs. CHI | Miles Sanders PHI - at WAS |
| 15 | Austin Ekeler LAC - vs. MIN | Austin Ekeler LAC - vs. MIN |
| 16 | Raheem Mostert SF - vs. ATL | Phillip Lindsay DEN - at KC |
| 17 | Miles Sanders PHI - at WAS | Raheem Mostert SF - vs. ATL |
| 18 | David Montgomery CHI - at GB | Devin Singletary BUF - at PIT |
| 19 | Joe Mixon CIN - vs. NE | Joe Mixon CIN - vs. NE |
| 20 | Devin Singletary BUF - at PIT | Le'Veon Bell NYJ - at BAL |
| 21 | James White NE - at CIN | James White NE - at CIN |
| 22 | Kareem Hunt CLE - at ARI | David Montgomery CHI - at GB |
| 23 | Le'Veon Bell NYJ - at BAL | Marlon Mack IND - at NO |
| 24 | Marlon Mack IND - at NO | Kenyan Drake ARI - vs. CLE |
| 25 | Sony Michel NE - at CIN | Kareem Hunt CLE - at ARI |
| 26 | Kenyan Drake ARI - vs. CLE | Adrian Peterson WAS - vs. PHI |
| 27 | Devonta Freeman ATL - at SF | Devonta Freeman ATL - at SF |
| 28 | Adrian Peterson WAS - vs. PHI | Sony Michel NE - at CIN |
| 29 | Patrick Laird MIA - at NYG | Patrick Laird MIA - at NYG |
| 30 | Royce Freeman DEN - at KC | DeAndre Washington OAK - vs. JAC |
| 31 | DeAndre Washington OAK - vs. JAC | Carlos Hyde HOU - at TEN |
| 32 | Ronald Jones II TB - at DET | Ronald Jones II TB - at DET |
| 33 | LeSean McCoy KC - vs. DEN | LeSean McCoy KC - vs. DEN |
| 34 | Jamaal Williams GB - vs. CHI | Jamaal Williams GB - vs. CHI |
| 35 | Carlos Hyde HOU - at TEN | Latavius Murray NO - vs. IND |
| 36 | Tarik Cohen CHI - at GB | Bo Scarbrough DET - vs. TB |
| 37 | Duke Johnson HOU - at TEN | Darwin Thompson KC - vs. DEN |
| 38 | Latavius Murray NO - vs. IND | Chris Thompson WAS - vs. PHI |
| 39 | Matt Breida SF - vs. ATL | Boston Scott PHI - at WAS |
| 40 | Benny Snell Jr. PIT - vs. BUF | Duke Johnson HOU - at TEN |
| 41 | Josh Jacobs OAK - vs. JAC | Matt Breida SF - vs. ATL |
| 42 | Bo Scarbrough DET - vs. TB | Tarik Cohen CHI - at GB |
| 43 | Peyton Barber TB - at DET | Royce Freeman DEN - at KC |
| 44 | Chris Thompson WAS - vs. PHI | Peyton Barber TB - at DET |
| 45 | Alexander Mattison MIN - at LAC | Nyheim Hines IND - at NO |
| 46 | David Johnson ARI - vs. CLE | Jalen Richard OAK - vs. JAC |
| 47 | Darwin Thompson KC - vs. DEN | David Johnson ARI - vs. CLE |
| 48 | Jalen Richard OAK - vs. JAC | Josh Jacobs OAK - vs. JAC |
| 49 | Nyheim Hines IND - at NO | Benny Snell Jr. PIT - vs. BUF |
| 50 | Boston Scott PHI - at WAS | Alexander Mattison MIN - at LAC |
